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Early satiety and postprandial fullness in gastroparesis correlate with gastroparesis severity, gastric emptying, and water load testing

Year: 2016
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Early satiety (ES) and postprandial fullness (PPF) are often present in gastroparesis, but the importance of these symptoms in gastroparesis has not been well-described. The aims were: (i) Characterize ES and PPF in patients with gastroparesis. (ii) Assess relationships of ES and PPF with etiology of gastroparesis, quality of life, body weight, gastric emptying, and water load testing. METHODS: Gastroparetic patients filled out questionnaires assessing symptoms (PAGI-SYM) and quality of life (PAGI-QOL, SF-36v2). Patients underwent gastric emptying scintigraphy and water load testing. KEY RESULTS: 198 patients with gastroparesis (134 IG, 64 DG) were evaluated. Early satiety was severe or very severe in 50% of patients. Postprandial fullness was severe or very severe in 60% of patients. Severity scores for ES and PPF were similar between idiopathic and diabetic gastroparesis. Increasing severity of ES and PPF were associated with other gastroparesis symptoms including nausea/vomiting, satiety/early fullness, bloating, and upper abdominal pain and GERD subscores. Increasing severity of ES and PPF were associated with increasing gastroparesis severity, decreased BMI, decreased quality of life from PAGI-QOL and SF-36 physical health. Increasing severity of ES and PPF were associated with increasing gastric retention of a solid meal and decreased volume during water load test. CONCLUSIONS & INFERENCES: Early satiety and PPF are commonly severe symptoms in both diabetic and idiopathic gastroparesis. Early satiety and PPF severity are associated with other gastroparesis symptom severities, body weight, quality of life, gastric emptying, and water load testing. Thus, ES and PPF are important symptoms characterizing gastroparesis. ClinicalTrials.gov number: NCT NCT01696747.
DOI: 10.1111/nmo.12981
Authors: H. P. Parkman, E. K. Hallinan, W. L. Hasler, G. Farrugia, K. L. Koch, L. Nguyen, W. J. Snape, T. L. Abell, R. W. McCallum, I. Sarosiek, P. J. Pasricha, J. Clarke, L. Miriel, J. Tonascia, F. Hamilton
Institutions: Temple University, Johns Hopkins University, University of Michigan, Mayo Clinic, Wake Forest University, Stanford University, California Pacific Medical Center, University of Louisville, Texas Tech University, National Institute of Diabetes and Digestive and Kidney Diseases
Language: English
Field: Medicine
Open Access status: bronze
Awards: Gastroparesis Consortium Continuation-Data Coordinating Center, Gastroparesis Clinical Research Consortium-University of Michigan Clinical Center, Continuation of the Scientific Data Research Center (SDRC) of the Gastroparesis Clinical Research Consortium (GpCRC) 4, Exploration of Subtypes of Gastroparesis and Gastroparesis-like Symptoms based on Physiological Testing, U of L Clinical Center to Investigate the Pathogenesis, Etiology, and Treatment of Gastroparesis through the NIDDK Gastroparesis Consortium, New England Gastropareis Consortium: Neurobiology of Gastroparesis, Advancing Science for the Diagnosis and Treatment of Gastroparesis, Temple University Gastroparesis Clinical Center, A multicenter, double-blind, randomized, placebo- controlled, parallel study to assess the efficacy of 5- HT4 agonist prucalopride for the treatment of diabetic and idiopathic gastroparesis
OpenAlex ID: W2536983064
FWCI: 10.18
Cites: 29
Cited by: 73
Related to: 10