Work

Achieving regio- and stereo-control in the fluorination of aziridines under acidic conditions

Year: 2016

Type: article

Abstract: We developed an efficient fluorination protocol that converts easily accessible aziridines into β-fluoroamines, which are important motifs in biologically active molecules. In contrast with traditional fluorination approaches, DMPU-HF has shown both higher reactivity and regioselectivity and good functional group tolerance; thus, a wide scope of β-fluoroamines can now be accessed conveniently. The stereochemical behavior of the ring opening depends on the substitution pattern of the aziridine substrate.

Source: Chemical Communications

DOI: 10.1039/c6cc07855a