Year: 2016
Type: article
Abstract: The emerging paradigm of precision cancer medicine, in which the use of molecular data at the point of care directly impacts patient treatment and clinical decision-making, has already had a substantial, direct clinical impact on many aspects of medical oncology. Advances in precision cancer medicine include well-established molecularly targeted therapies for patients with BRAF-mutant metastatic melanoma [1], those with EGFR-mutant [2] or ALK-mutant [3] non-small-cell lung cancer, and those with BCR–ABL-translocation-positive chronic myelogenous leukemia [4]. In addition, the introduction of large-scale genomic technologies at the point of care [5–7] has catalyzed discoveries in translational oncology and is driving new research that aims to dissect selective responses to targeted, immune-driven therapies and to chemotherapies, as well as identifying novel targets for which therapies are now in development. Indeed, propelled by the ability to generate increasingly complex molecular data directly from patient tumor and germ-line samples, the cycle of translating discoveries into clinical practice may be accelerating.
Source: Genome Medicine
Authors: Michael F. Berger, Eliezer M. Van Allen
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $5,290
Funder: National Cancer Institute
Award: Cancer Center Support Grant
OpenAlex ID: W2537696406