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Fabrication of RNA 3D Nanoprisms for Loading and Protection of Small RNAs and Model Drugs

Year: 2016
Type: article
Abstract: Constructing containers with defined shape and size to load and protect therapeutics and subsequently control their release in the human body has long been a dream. The fabrication of 3D RNA prisms, characterized by atomic force microscopy, cryo-electron microscopy, dynamic light scattering, and polyacrylamide gel electrophoresis, is reported for the loading and protection of small molecules, proteins, small RNA molecules, and their controlled release.
DOI: 10.1002/adma.201603180
Authors: Emil F. Khisamutdinov, Daniel L. Jasinski, Hui Li, Kaiming Zhang, Wah Chiu, Peixuan Guo
Language: English
Open Access status: green
Awards: G1378833086, G2526390019, G5226551089, P30 - Core Grant for Vision Research, G574044863, The Center for HIV RNA Studies (CRNA), 3 D Electron Microscopy of Macromolecules, G9000058782, G9000068738, G9000129597, G9000223721, G9000225717
OpenAlex ID: W2537703166
FWCI: 3.762
Cites: 54
Cited by: 65
Related to: 10