Work

Linker-free incorporation of carbohydrates into in vitro displayed macrocyclic peptides

Year: 2016

Type: article

Abstract: We report a strategy for efficient post-translational modification of a library of ribosomally-translated peptides by activation and elimination of cysteine to dehydroalanine then conjugate addition of a range of exogenous thiols, with an emphasis on carbohydrates.

Source: Chemical Science

DOI: 10.1039/c6sc04381j

Authors: S. A. K. Jongkees, S. Umemoto, H. Suga

Institutions: The University of Tokyo, Japan Science and Technology Agency

Language: English

Topic: Chemical Synthesis and Analysis

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: diamond

Funder: Japan Society for the Promotion of Science

Award: G664505991