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F5‐01‐03: Surgery and Cognitive Decline in the Wisconsin Registry for Alzheimer's Prevention (WRAP) Database

Year: 2016
Type: article
Study design: Observational Study
Abstract: The effects of surgery and anesthesia on incident dementia are unknown. Accordingly, in a sample enriched for healthy adult children of parents with Alzheimer's disease, psychometric test performance at enrollment (visit 1) and at 4 years later (visit 2) was compared in participants with and without surgery in the 9 year interval from 5 years before visit 1 to visit 2. Records of surgical procedures requiring general, spinal or epidural anesthesia were obtained. Cardiac and intracranial procedures were excluded. Neuropsychological test scores were grouped into a memory domain (Immediate Memory (IM), Verbal Learning and Memory (VLM)), and an executive function domain (Speed and Flexibility (SF) and Working Memory (WM)) by factor analysis, and standardized to z-scores. Memory and executive function performances were classified to be within robust limits (WRL) or below robust limits (BRL) if a factor score within a domain was 1.5 standard deviations or more below internal norms adjusted for age, gender, and literacy. (Koscik RL et al. Dement Geriatr Cogn Disord. 2014;38(1-2):16-30.). 312 participants had 506 qualifying surgeries. 652 participants served as no-surgery controls. 17.5% of participants with no memory deficits (WRL) at visit 1 having surgery between visit 1 and 2 had memory BRL at visit 2 compared to 10.1% in the no-surgery group (p=0.022). The number of surgeries from 5 years before enrollment to visit 2 was a significant predictor of a decline in IM scores in those having surgery between visit 1 and 2 (p=0.012). ApoE4 positive participants who had surgery between visits 1 and 2 had a greater decline in executive function at visit 2 than ApoE4 negative participants who had surgery between visits 1 and 2 (p=0.031). Participants having surgery were at increased risk for cognitive decrements than participants who did not have surgery.
DOI: 10.1016/j.jalz.2016.06.685
Language: English
Open Access status: bronze
OpenAlex ID: W2538015835
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