Year: 2016
Type: review
Abstract: cause of death in high-income countries, accounting for 3%-8% of total deaths, and it was the sixth leading cause of death in nations of low and middle income, accounting for 4%-9% of total deaths 3 .In this same report, COPD was also estimated to be the seventh and 10th leading cause of disability-adjusted life years in countries of high income and in those of low or middle income, respectively 3 .COPD tissues are characterized by chronic inflammation, mucus metaplasia, alveolar destruction, and structural cell apoptosis 2 .It is important to point out; however, that the underlying mechanisms of the pathogenesis of COPD have not yet been adequately elucidated, hindering the successful development of disease-modifying therapeutics.Recently, mitochondria/mitochondrial dysfunction has been highlighted in a variety of disorders and human health 4 .Mitochondria take important parts not only in cellular respiration but also in other fundamental cellular functions including metabolism, innate and adaptive immune signaling, calcium homeostasis, senescence, and cell death.Accordingly, recent studies have revealed unprecedented roles of mitochondrial molecules which play in the context of COPD pathogenesis.These recent advancements on mitochondrial biology have enabled us to envisage that COPD pathogenesis could be understood better if it is focused on from the mitochondrial
Authors: Min-Jong Kang, Gerald S. Shadel
Institution: Yale University
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W2538506131