Immune Response Modulation of Conjugated Agonists with Changing Linker Length
Year: 2016
Type: article
Abstract: We report immune response modulation with linked Toll-like receptor (TLR) agonists. Conjugating two agonists of synergistic TLRs induce an increase in immune activity compared to equal molarity of soluble agonists. Additionally, varying the distance between the agonists by changing the linker length alters the level of macrophage NF-κB activity as well as primary bone marrow derived dendritic cell IL-6 production. This modulation is effected by the size of the agonists and the pairing of the stimulated TLRs. The sensitivity of linker-length-dependent immune activity of conjugated agonists provides the potential for developing application specific therapeutics.
Source: ACS Chemical Biology
Authors: Keun Ah Ryu, Katarzyna Slowinska, Troy Moore, Aaron Esser-Kahn
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
Awards: Collagen Hybrid Peptides and Facilitators in Targeting-Free Cell Selection and Uptake of Maliganant Cells, G2996456677, G3533071707, G4604635169, Directing The Immune System Via Polymeric Combinations of Molecular Signals, Determining the Mechanism of Activation of Linked Agonists Synergies, Cancer Center Support Grant
OpenAlex ID: W2538635119