Work

Autophagy in brain ischemia

Year: 2011

Type: article

Abstract: Autophagy is an intracellular process of macromolecule and organelle degradation, which plays an important role both in maintaining homeostasis and in responding to various harmful stimuli. Recent studies clearly indicate upregulation of autophagy in neurons challenged with brain ischemia. In this paper we present biosynthesis of autophagosomes as well as the role and molecular mechanisms of basal and induced neuronal autophagy. We have also reviewed recently published papers concerning the potential role of autophagy in brain ischemia. Results of both in vivo and in vitro experimental studies indicate that signaling pathways related to autophagy might become a target of new neuroprotective strategies.

Source: Postępy Higieny i Medycyny Doświadczalnej

DOI: 10.5604/17322693.955650

Authors: Alicja Kost, Daniela Kasprowska, Krzysztof Łabuzek, Ryszard Wiaderkiewicz, Bożena Gabryel

Institution: Medical University of Silesia

Language: Polish

Topic: Autophagy in Disease and Therapy

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W2041060374

FWCI: 0.105

Cites: 87

Cited by: 9

Related to: 10