Nutritional interventions or exposures in infants and children aged up to 3 years and their effects on subsequent risk of overweight, obesity and body fat: a systematic review of systematic reviews
Year: 2016
Type: review
Study design: Systematic Review
Abstract: This study, performed as part of the international EarlyNutrition research project (http://www.project-earlynutrition.eu), provides a systematic review of systematic reviews on the effects of nutritional interventions or exposures in children (up to 3 years of age) on the subsequent risk of obesity, overweight and adiposity. Electronic databases (including MEDLINE, Embase and Cochrane Library) were searched up until September 2015. Forty systematic reviews were included. A consistent association of breastfeeding with a modest reduction in the risk of later overweight and obesity in childhood and adulthood was found (the odds decreased by 13% based on high-quality studies), but residual confounding cannot be excluded. Lowering the protein content of infant formula is a promising intervention to reduce the risk of later overweight and obesity in children. There is no consistent evidence of an association of the age of introducing complementary foods, sugar-sweetened beverage or energy intake in early childhood with later overweight/obesity, but there are some indications of an association of protein intake during the complementary feeding period with later overweight/obesity. There was inadequate evidence to determine the effects of other nutritional interventions or exposures, including modifications of infant formula composition, fat intake or consumption of different food groups.
Source: Obesity Reviews
DOI: 10.1111/obr.12476
Institutions: Medical University of Warsaw, Amsterdam UMC Location Vrije Universiteit Amsterdam, King's College London, Kings Health Partners, University Hospital Southampton NHS Foundation Trust, NIHR Southampton Biomedical Research Centre, MRC Lifecourse Epidemiology Unit, University of Southampton, Ludwig-Maximilians-Universität München, Emma Kinderziekenhuis, Amsterdam University Medical Centers
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: Danone, Action Medical Research, National Institute for Health and Care Research, British Heart Foundation, Tommy's Baby Charity, King's College London, European Commission, Klinički Centar Vojvodine, Tommy's, Nestec, National Institute for Health Research Southampton Biomedical Research Centre, Medical Research Council
Awards: The UPBEAT RCT mother-child study. Stratifying and treating obese pregnant women to prevent adverse pregnancy, perinatal and longer term outcomes., G1277089031, Food-based solutions for Optimal vitamin D Nutrition and health through the life cycle, G2446105952, G2473961061, G3207356259, NIHR Senior Investigator Award, NIHR Senior Investigator Award, Improving pregnancy outcome in obese women, G393177772, G462585257, G5605571342, G5702163051, Epigenetic biomarkers and determinants of cardiovascular risk in children, Nutrition, Development and Lifelong Health: Studies in European Populations, Long-term effects of early nutrition on later health
OpenAlex ID: W2539274360