Work

Synthesis and NAD(P)H:Quinone oxidoreductase 1 inducer activity of acetamide and pyridine-3-carbonitrile derivatives

Year: 2016

Type: article

Abstract: Acetamide derivatives and one pyridone derivative were prepared. The structure of the synthesized compounds was verified through elemental analyses,1H -NMR and13C- NMR, IR spectra. The NQO1 inducer activity of the synthesized compounds was evaluated using a quantitative bioassay in Hepa1c1c7 murine hepatoma cells. The acetamide derivatives showed weak activity, with the 3-ethylphenyl being more potent than the 2-ethylphenyl derivative. The pyridone derivative was inactive.

Source: Discovery Research Portal (University of Dundee)