The Promise and Challenge of Induced Pluripotent Stem Cells for Cardiovascular Applications
Year: 2016
Type: article
Abstract: The recent discovery of human-induced pluripotent stem cells (iPSCs) has revolutionized the field of stem cells. iPSCs have demonstrated that biological development is not an irreversible process and that mature adult somatic cells can be induced to become pluripotent. This breakthrough is projected to advance our current understanding of many disease processes and revolutionize the approach to effective therapeutics. Despite the great promise of iPSCs, many translational challenges still remain. In this article, we review the basic concept of induction of pluripotency as a novel approach to understand cardiac regeneration, cardiovascular disease modeling and drug discovery. We critically reflect on the current results of preclinical and clinical studies using iPSCs for these applications with appropriate emphasis on the challenges facing clinical translation.
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $4,750
Awards: Together: Transforming and Translating Discovery to Improve Health, Protection of Ischemic Myocardium, G2534692569, Patient Oriented Research in Cardiovascular Regeneration, The paradoxical role of CDKN2B in blood vessel sprouting and maturation, G428580802, G4850166151, G4861230988, G5601728548, University of Louisville Regional Clinical Center for the CCTRN, Cell Characterization and Imaging for Regenerative Therapies in Ischemic Diseases, UFRCC for Cardiovascular Cell Therapy Research Network, G7950770619, G8438182560, G9000211062, T32 Training Program in Mechanisms and Innovation in Vascular Disease, G930967824
OpenAlex ID: W2540144723