Work

HMGB2 holds the key to the senescence-associated secretory phenotype

Year: 2016

Type: article

Abstract: The senescence-associated secretory phenotype (SASP) is a hallmark of senescence with an important physiological impact, but how it is established is unclear. In this issue, Aird et al. (2016. J. Cell Biol. https://doi.org/10.1083/jcb.201608026) describe how chromatin-bound HMGB2 fine tunes SASP expression by avoiding heterochromatin spreading.

Source: The Journal of Cell Biology

DOI: 10.1083/jcb.201610044

Authors: Ana Guerrero, Jesús Gil

Institutions: Imperial College London, Medical Research Council

Language: English

Topic: Telomeres, Telomerase, and Senescence

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Funder: Medical Research Council

Awards: G4627821567, G5221051721