Work

RNA editing as an activator of self-renewal in cancer

Year: 2016

Type: article

Abstract: Malignant transformation and cancer progression are complex processes caused by dysfunction of genetic programs. It is well established that aberrant posttranscriptional regulation of messenger RNA contributes the pathogenesis of many types of tumors initiation, progression and treatment evasion (1). One such mechanism is the IFN-γ pathway activation of the ADAR1-p150 isoform in chronic myeloid leukemia (CML) progenitors. This pathway was shown to lead to activation of expression of self-renewal genes (2).

Source: Stem Cell Investigation

DOI: 10.21037/sci.2016.10.01

Authors: Igal Germanguz, William E. Lowry

Institutions: University of California, Los Angeles, UCLA Jonsson Comprehensive Cancer Center

Language: English

Topic: RNA regulation and disease

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: University of Oklahoma, National Institutes of Health, University of Oklahoma Health Sciences Center, National Institute of General Medical Sciences