Inflammatory monocytes hinder antiviral B cell responses
Year: 2016
Type: article
Abstract: inflammatory monocytes. These myeloid cells were recruited to lymph nodes draining LCMV infection sites in a type I interferon-, CCR2-dependent fashion and they suppressed antiviral B cell responses by virtue of their ability to produce nitric oxide. Depletion of inflammatory monocytes, inhibition of their lymph node recruitment or impairment of their nitric oxide-producing ability enhanced LCMV-specific B cell survival and led to robust neutralizing antibody production. In conclusion, our results identify inflammatory monocytes as critical gatekeepers that prevent antiviral B cell responses and suggest that certain viruses take advantage of these cells to prolong their persistence within the host.
Source: Science Immunology
Authors: Stefano Sammicheli, Mirela Kuka, Pietro Di Lucia, Nereida Jiménez de Oya, Marco De Giovanni, Jessica Fioravanti, Claudia Cristofani, Carmela G. Maganuco, Benedict Fallet, Lucia Ganzer, Laura Sironi, Marta Mainetti, Renato Ostuni, Kevin Larimore, Philip D. Greenberg, Juan Carlos de la Torre, Luca G. Guidotti, Matteo Iannacone
Language: English
Topic: Immune cells in cancer
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2545036041