Hedgehog Signaling is a Mediator of the Gastric Immune Response to Helicobacter pylori Infection
Year: 2014
Type: article
Abstract: Significance Helicobacter pylori (H.pylori) infection causes gastric inflammation and is associated with the development of gastric disease.To prevent severe disease occurrence it is essential to determine what bacterial or host factors play a role in the pathogenesis of the organism.The role of Sonic Hedgehog (Shh) in mediating gastric inflammatory disease has not been studied.This lack of knowledge of the acute immune mechanisms underlying H. pylori infection obstructs our understanding of H.pylori persistence and associated disease development.This knowledge will aid in determining dysregulated gastric signaling mechanisms and may be useful as a predictive marker for identifying those at risk to develop severe outcomes associated with H. pylori infection.
Author: Michael A. Schumacher
Institution: University of Cincinnati
Language: English
Subfield: Gastroenterology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2545484997