Work

Building Viral Replication Organelles: Close Encounters of the Membrane Types

Year: 2016

Type: article

Abstract: OverviewPositive-strand (+)RNA viruses are important and emerging pathogens of humans, animals, and plants.Upon infection, they induce the formation of specialized membranous replication organelles with unique lipid composition to facilitate robust virus replication.In this article, the authors discuss the proviral role of virus-induced membrane contact sites (vMCSs).The emerging picture is that vMCSs channel lipids to viral membranes and tune the lipid composition for optimal generation and functioning of replication organelles.

Source: PLoS Pathogens

DOI: 10.1371/journal.ppat.1005912

Authors: Peter D. Nagy, Jeroen R. P. M. Strating, Frank J. M. van Kuppeveld

Institutions: University of Kentucky, Utrecht University

Language: English

Topic: Cellular transport and secretion

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $3,043

Funders: National Science Foundation, Nederlandse Organisatie voor Wetenschappelijk Onderzoek