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Adenovirus serotype 5 vaccine vectors trigger IL-27–dependent inhibitory CD4 + T cell responses that impair CD8 + T cell function

Year: 2016

Type: article

Abstract: T cell magnitude and function following Ad5 vector immunization. A deeper understanding of the cytokine networks and transcriptional profiles induced by vaccine vectors should lead to strategies to improve the immunogenicity and protective efficacy of viral vector-based vaccines.

Source: Science Immunology

DOI: 10.1126/sciimmunol.aaf7643

Authors: Rafael A. Larocca, Nicholas M. Provine, Malika Aid, M. Justin Iampietro, Erica N. Borducchi, Alexander Badamchi-Zadeh, Peter Abbink, David Ng’ang’a, Christine A. Bricault, Eryn Blass, Pablo Penaloza-MacMaster, Kathryn E. Stephenson, Dan H. Barouch

Institutions: Beth Israel Deaconess Medical Center, Harvard University, Northwestern University, Ragon Institute of MGH, MIT and Harvard, Massachusetts Institute of Technology

Language: English

Topic: Immunotherapy and Immune Responses

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of Allergy and Infectious Diseases

Awards: Diversity of Immune Responses Elicited by HIV Vaccines, Novel Heterologous Adenovirus Prime-Boost HIV-1 Vaccine, Novel Ad/MVA and Ad/Protein HIV-1 Vaccines, Molecular Basis of Viral Infectivity, Multidisciplinary HIV Training Program, Harvard University Center for AIDS Research

OpenAlex ID: W2546994994

FWCI: 1.617

Cites: 48

Cited by: 20

Related to: 10