Year: 2015
Type: dissertation
Abstract: Post-translational modifications (PTMs) are an important step in the formation of a mature protein. While much is known about some PTMs such as Phosphorylation, there are other PTMs such as Cysteine S-sulfenylation that are currently being researched and analyzed. For this project, an algorithm, Bit-Motif, was developed to analyze modification sites of PTMs by discovering statistically significant motifs around these sites. These motifs were then used as features for a Support Vector Machine to build a prediction model for PTM sites, called Prediction Using Motifs for PTMs (PUMP).
Author: Johnson, Steven Michael
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2547366186