Potassium currents in the heart: functional roles in repolarization, arrhythmia and therapeutics
Year: 2016
Type: article
Abstract: This is the second of the two White Papers from the fourth UC Davis Cardiovascular SymposiumSystems Approach to Understanding Cardiac Excitation–Contraction Coupling and Arrhythmias(3–4 March 2016), a biennial event that brings together leading experts in different fields of cardiovascular research. The theme of the 2016 symposium was ‘K+channels and regulation’, and the objectives of the conference were severalfold: (1) to identify current knowledge gaps; (2) to understand what may go wrong in the diseased heart and why; (3) to identify possible novel therapeutic targets; and (4) to further the development of systems biology approaches to decipher the molecular mechanisms and treatment of cardiac arrhythmias. The sessions of the Symposium focusing on the functional roles of the cardiac K+channel in health and disease, as well as K+channels as therapeutic targets, were contributed by Ye Chen‐Izu, Gideon Koren, James Weiss, David Paterson, David Christini, Dobromir Dobrev, Jordi Heijman, Thomas O'Hara, Crystal Ripplinger, Zhilin Qu, Jamie Vandenberg, Colleen Clancy, Isabelle Deschenes, Leighton Izu, Tamas Banyasz, Andras Varro, Heike Wulff, Eleonora Grandi, Michael Sanguinetti, Donald Bers, Jeanne Nerbonne and Nipavan Chiamvimonvat as speakers and panel discussants. This article summarizes state‐of‐the‐art knowledge and controversies on the functional roles of cardiac K+channels in normal and diseased heart. We endeavour to integrate current knowledge at multiple scales, from the single cell to the whole organ levels, and from both experimental and computational studies.
Source: The Journal of Physiology
DOI: 10.1113/jp272883
Authors: Nipavan Chiamvimonvat, Ye Chen‐Izu, Colleen E. Clancy, Isabelle Deschenes, Dobromir Dobrev, Jordi Heijman, Leighton Izu, Zhilin Qu, Crystal M. Ripplinger, Jamie I. Vandenberg, James N. Weiss, Gideon Koren, Tamas Banyasz, Eleonora Grandi, Michael C. Sanguinetti, Donald M. Bers, Jeanne M. Nerbonne
Institutions: VA Northern California Health Care System, University of California, Davis, MetroHealth Medical Center, Case Western Reserve University, West German Heart and Vascular Center Essen, University of Duisburg-Essen, Maastricht University, University of California, Los Angeles, Victor Chang Cardiac Research Institute, Brown University, Rhode Island Hospital, University of Debrecen, University of Utah, Washington University in St. Louis, Washington University Medical Center
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: G1185946596, G1351713346, G1508866, G1852817908, G2536180224, G2654977352, G32515035, Systems Approach to understanding Excitation-Coupling and Cardiac Arrhythmias, G355628465, G4085294414, G5496526517, Phospholemman and Na-Pump Function in Cardiac Myocytes, G6061583175, Ionic Control of Cardiac Muscle Contraction: EC Coupling, Translational Study of Cardiac Dysfunction, G8784751317, Sympathetic remodeling and ventricular arrhythmia, Functional interactions of cardiac ion channels
OpenAlex ID: W2548502736