Work

Sorting receptor SORLA: cellular mechanisms and implications for disease

Year: 2016

Type: review

Abstract: Sorting-related receptor with A-type repeats (SORLA) is an intracellular sorting receptor that directs cargo proteins, such as kinases, phosphatases, and signaling receptors, to their correct location within the cell. The activity of SORLA assures proper function of cells and tissues, and receptor dysfunction is the underlying cause of common human malignancies, including Alzheimer's disease, atherosclerosis, and obesity. Here, we discuss the molecular mechanisms that govern sorting of SORLA and its cargo in multiple cell types, and why genetic defects in this receptor results in devastating diseases.

Source: Cellular and Molecular Life Sciences

DOI: 10.1007/s00018-016-2410-z

Authors: Vanessa Schmidt, Aygul Subkhangulova, Thomas E. Willnow

Institutions: Max Delbrück Center, Berlin Institute of Health at Charité - Universitätsmedizin Berlin

Language: English

Topic: Cellular transport and secretion

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,290