Work

Akkermansia muciniphila mediates negative effects of IFNγ on glucose metabolism

Year: 2016

Type: article

Abstract: Cross-talk between the gut microbiota and the host immune system regulates host metabolism, and its dysregulation can cause metabolic disease. Here, we show that the gut microbe Akkermansia muciniphila can mediate negative effects of IFNγ on glucose tolerance. In IFNγ-deficient mice, A. muciniphila is significantly increased and restoration of IFNγ levels reduces A. muciniphila abundance. We further show that IFNγ-knockout mice whose microbiota does not contain A. muciniphila do not show improvement in glucose tolerance and adding back A. muciniphila promoted enhanced glucose tolerance. We go on to identify Irgm1 as an IFNγ-regulated gene in the mouse ileum that controls gut A. muciniphila levels. A. muciniphila is also linked to IFNγ-regulated gene expression in the intestine and glucose parameters in humans, suggesting that this trialogue between IFNγ, A. muciniphila and glucose tolerance might be an evolutionally conserved mechanism regulating metabolic health in mice and humans.

Source: Nature Communications

DOI: 10.1038/ncomms13329

Authors: Renee L. Greer, Xiaoxi Dong, Ana Carolina F. Moraes, Ryszard A. Zielke, Gabriel R. Fernandes, Ekaterina Peremyslova, Stephany Vasquez-Perez, Alexi A. Schoenborn, Everton P. Gomes, Alexandre C. Pereira, Sandra R. G. Ferreira, Michael Yao, Ivan J. Fuss, Warren Strober, Aleksandra E. Sikora, Gregory A. Taylor, Ajay S. Gulati, Andrey Morgun, Natalia Shulzhenko

Institutions: Oregon State University, Universidade de São Paulo, Fundação Oswaldo Cruz, University of North Carolina at Chapel Hill, Instituto do Coração - HCFMUSP, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Duke University, Duke Medical Center

Language: English

Topic: Gut microbiota and health

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $6,990

Funders: U.S. Department of Veterans Affairs, Oregon State University, Fundação de Amparo à Pesquisa do Estado de São Paulo, National Institutes of Health, National Institute of Allergy and Infectious Diseases, National Institute of Diabetes and Digestive and Kidney Diseases

Awards: G1795656365, Analysis of the intestinal microbiota in adults with different dietary patterns and possible associations with inflammatory status, insulin sensitivity and body adiposity, Influences of the enteric microbiota on intestinal stem cell biology, Gut microbiota mediates the interplay between immunity and glucose metabolism, Anti-IL-12p40 Treatment of CVID Enteropathy: Gene Expression/Microbiota Analysis

OpenAlex ID: W2549293350

FWCI: 12.65

Cites: 69

Cited by: 279

Related to: 10