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Cover Picture: Catalytic Cycloisomerization–Fluorination Sequence of N‐Propargyl Amides by Iodoarene/HF⋅Pyridine/Selectfluor Systems (Asian J. Org. Chem. 11/2016)

Year: 2016

Type: article

Abstract: The combination of cyclization and fluorination in a single operation provides a straightforward and efficient approach to fluorinated heterocycles from unsaturated compounds bearing a heteroatom nucleophile. In this study, a metal-free cycloisomerization–fluorination sequence of N-propargyl amides catalyzed by an iodine(III) species is reported. The iodine(III) catalyst is in situ generated from iodoarene as a precatalyst with Selectfluor as a fluorinating oxidant in the presence of HF⋅pyridine. More information can be found in the Communication by Akio Saito et al. on page 1314 in Issue 11, 2016 (DOI: 10.1002/ajoc.201600383).

Source: Asian Journal of Organic Chemistry

DOI: 10.1002/ajoc.201600484

Authors: Naoki Asari, Yusuke Takemoto, Yukino Shinomoto, Takuma Yagyu, Akira Yoshimura, Viktor V. Zhdankin, Akio Saito

Institutions: Tokyo University of Agriculture and Technology, University of Minnesota, Duluth

Language: English

Topic: Fluorine in Organic Chemistry

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

Open Access status: bronze

OpenAlex ID: W2549504266

FWCI:

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