Work

Receptory aktywowane proliferatorami peroksysomów (PPAR). Właściwości antyproliferacyjne

Year: 2011

Type: article

Abstract: Peroxisome proliferator-activated receptors (PPAR) are transcription factors that belong to the hormone nuclear receptor superfamily. Their main role is control of fatty acid metabolism and to maintain glucose homeostasis. Isotype γ of PPAR can also be implicated in proliferation and cellular differentiation of both normal and cancer cells. Compounds that are PPARγ ligands have a negative influence on cancer cells and can induce apoptosis, inhibit proliferation or induce cellular differentiation of these cells. This review summarizes general information about PPAR and focuses on anticancer activities of PPARγ ligands and their use in combined therapy. Combination treatment using PPARγ ligands and other agents, especially retinoids and specific kinase inhibitors, may be an effective strategy for chemoprevention and treatment of some cancers.

Source: Postępy Higieny i Medycyny Doświadczalnej

DOI: 10.5604/17322693.949463

Authors: Anna Hojka, Andrzej Rapak

Institution: Ludwik Hirszfeld Institute of Immunology and Experimental Therapy

Language: Polish

Topic: Peroxisome Proliferator-Activated Receptors

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W2342414790

FWCI:

Cites: 82

Cited by: 10

Related to: 10