Work

Endothelin: Ominous Player in Breast Cancer.

Year: 2016

Type: article

Abstract: The function of endothelin (ET) in breast cancer is now under focus and there is a growing interest in the role of ET axis (endothelin and its receptors) in cancer. Several studies have reported a much higher expression of ET-1 among all other isoforms (ET-1, ET-2 and ET-3) in breast carcinomas than in normal breast tissue [1-3], indicating that the ET-1 system is primarily associated with breast cancer. ET-1 exerts its physiological effects via two receptors, ETA and ETB, which are Gprotein-coupled transmembrane receptors found in both vascular and nonvascular tissues. Currently there are several evidences that ET-1 may modulate mitogenesis, apoptosis, angiogenesis, tumor invasion and development of metastases by exerting its autocrine or paracrine action [4,5]. The diverse biological roles played by ET-1 in breast cancer have been represented in Figure 1.

Source: PubMed

Authors: Anuradha Ratna, Salil K Das

Institution: Meharry Medical College

Language: English

Topic: Nitric Oxide and Endothelin Effects

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute on Minority Health and Health Disparities

Award: Meharry Clinical and Translational Research Center (MeTRC)