Year: 2012
Type: article
Study design: Observational Study
Abstract: Background and Objectives : The clinical profile of hepatorenal syndrome (HRS) patients admitted in a tertiary care hospital of Punjab was studied. Methods :In this prospective study all the patients of chronic liver disease with renal involvement fulfilling the International Ascites Club criteria of HRS were evaluated over a period of one and a half year.Result : Forty-two patients were diagnosed to have HRS and were included in the study.The incidence of HRS was 0.275% of hospital medical admissions.Alcoholic cirrhosis was the etiology in 71.5% of patients.Most of the patients of HRS received a combination of dopamine, albumin and terlipressin.The mortality rate was found to be approximately 60%.Variables amongst survival versus non-survival groups were analyzed.Oliguria and hepatic encephalopathy were more predominant in non-survival group.Serum bilirubin, hypoalbuminemia, hyponatremia, coagulopathy and urine osmolality was higher in non-survival group.Patients with Child-Pugh Score less than 10 had a better survival.Conclusion : The poor prognostic factors in non-survival group were presence of ascites, severe jaundice, hepatic encephalopathy, alcohol abuse, hypoalbuminemia, progressive renal failure and a Child-Pugh Score > 10.Thus, HRS is not uncommon and needs proper diagnosis and prompt treatment to ensure better outcome.
DOI: 10.5005/jogi-2-1-38
Authors: Sandeep Puri, Praveen Rishi, Rajoo Singh Chhina, Rajdeep Singh Chhina, Amit Bery, Jaswinder Singh Sandhu
Institution: Dayanand Medical College & Hospital
Language: English
Subfield: Hepatology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2549957740