Work

A TSLP-complement axis mediates neutrophil killing of methicillin-resistant Staphylococcus aureus

Year: 2016

Type: article

Abstract: , another clinically important cause of human skin infections. Unexpectedly, TSLP mechanistically mediates its antibacterial effect by directly engaging the complement C5 system to modulate production of reactive oxygen species by neutrophils. Thus, TSLP increases MRSA killing in a neutrophil- and complement-dependent manner, revealing a key connection between TSLP and the innate complement system, with potentially important therapeutic implications for control of MRSA infection.

Source: Science Immunology

DOI: 10.1126/sciimmunol.aaf8471

Authors: Erin E. West, Rosanne Spolski, Majid Kazemian, Zu Xi Yu, Claudia Kemper, Warren J. Leonard

Institutions: National Institutes of Health, National Heart, Lung, and Blood Institute, King's College London

Language: English

Topic: Complement system in diseases

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Wellcome Trust, National Institutes of Health