Work

Small molecules inhibiting Keap1–Nrf2 protein–protein interactions: a novel approach to activate Nrf2 function

Year: 2016

Type: article

Abstract: different approaches, including high-throughput screening, target-based virtual screening, structure-based optimization, and fragment-based drug design. This review aims to highlight the recently discovered small-molecule inhibitors as well as their therapeutic potential.

Source: MedChemComm

DOI: 10.1039/c6md00500d

Authors: Chunlin Zhuang, Zhongli Wu, Chengguo Xing, Zhenyuan Miao

Institutions: Second Military Medical University, University of Florida Health, University of Florida

Language: English

Topic: Genomics, phytochemicals, and oxidative stress

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Natural Science Foundation of China, Second Military Medical University, National Institutes of Health, National Cancer Institute