Building confidence in quantitative systems pharmacology models: An engineer's guide to exploring the rationale in model design and development
Year: 2016
Type: review
Abstract: This tutorial promotes good practice for exploring the rationale of systems pharmacology models. A safety systems engineering inspired notation approach provides much needed rigor and transparency in development and application of models for therapeutic discovery and design of intervention strategies. Structured arguments over a model's development, underpinning biological knowledge, and analyses of model behaviors are constructed to determine the confidence that a model is fit for the purpose for which it will be applied.
DOI: 10.1002/psp4.12157
Institutions: University of York, Hull York Medical School
Language: English
Subfield: Statistics and Probability
Field: Mathematics
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $2,315
Awards: G27711899, G314943820
OpenAlex ID: W2551394389