Work

Progress and prospect of mesenchymal stem cell-based therapy in atherosclerosis.

Year: 2016

Type: article

Abstract: Atherosclerosis is a chronic inflammatory disease of the arterial intima, occurring usually in the aged populations who are suffering from hypertension, dyslipidemia and diabetes for a long time. Research on atherosclerosis has shown that macrophage foam cell formation, inflammation, dyslipidemia and immune cells infiltration are all involved in regulating the onset and progression of atherosclerosis. Mesenchymal stem cells (MSCs) originated from different kinds of tissue are a group of cells possessing well-established self-renewal and multipotent differentiation properties as well as immunomodulatory and anti-inflammatory roles. Recent studies have displayed their dyslipidemia regulation functions. Transplantation of MSCs to atherosclerotic patients might be a new multifactorial therapeutic strategy to improve atherosclerosis. This review updates the advancement on MSCs and atherosclerosis.

Source: PubMed Central

Authors: Ximei Zhang, Feng Huang, Yanming Chen, Xiaoxian Qian, Song Guo Zheng

Institutions: Sun Yat-sen University, Third Affiliated Hospital of Sun Yat-sen University, Pennsylvania State University, Penn State Milton S. Hershey Medical Center

Language: English

Topic: Mesenchymal stem cell research

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of Arthritis and Musculoskeletal and Skin Diseases

Award: Therapeutic immunoregulation mediated by TGF-beta-induced iTregs in autoimmune arthritis