Year: 2016
Type: article
Abstract: Formylglycine‐generating enzyme (FGE) is an O2‐utilizing oxidase that converts specific cysteine residues of client proteins to formylglycine. We show that CuI is an integral cofactor of this enzyme and binds with high affinity (KD=of 10−17 m) to a pair of active‐site cysteines. These findings establish FGE as a novel type of copper enzyme.
Source: ChemBioChem
Institutions: University of Basel, ETH Zurich, Laboratory of Physical Chemistry
Language: English
Subfield: Inorganic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $4,430
OpenAlex ID: W2551998204