Work

KDM5 lysine demethylases are involved in maintenance of 3′UTR length

Year: 2016

Type: article

Abstract: . Our findings suggest both a novel role for this family of demethylases and a novel targetable mechanism for 3'UTR processing.

Source: Science Advances

DOI: 10.1126/sciadv.1501662

Authors: Lauren P. Blair, Zongzhi Liu, Ramon Lorenzo D. Labitigan, Lizhen Wu, Dinghai Zheng, Zheng Xia, Erica L. Pearson, Fathima I. Nazeer, Jian Cao, Sabine M. Lang, Rachel J. Rines, Samuel G. Mackintosh, Claire L. Moore, Wei Li, Bin Tian, Alan J. Tackett, Qin Yan

Institutions: Yale University, Rutgers New Jersey Medical School, Baylor College of Medicine, Dan L Duncan Comprehensive Cancer Center, Tufts University, University of Arkansas for Medical Sciences

Language: English

Topic: RNA Research and Splicing

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $4,500

Funders: American Cancer Society, Breast Cancer Alliance, Cancer Prevention and Research Institute of Texas, Li Ka Shing Foundation, Yale Cancer Center, National Human Genome Research Institute, National Cancer Institute, National Institute of General Medical Sciences, Division of Molecular and Cellular Biosciences, National Center for Advancing Translational Sciences, Congressionally Directed Medical Research Programs

Awards: G1652003891, Computational and Experimental Modeling of Epigenetic DNA Methylation, G2077139555, Center for Microbial Pathogenesis and Host Inflammatory Responses, G2395004044, G2486819142, G2628658239, G2683385012, IDENTIFYING EPIGENETIC CHANGES CRITICAL FOR TRASTUZUMAB RESISTANCE, G2822256486, G292431030, G30324867, G3423148615, G4194377801, G4284848066, Epigenetic Mechanisms of Breast Cancer Metastasis, Targeting an Epigenetic Regulator to Suppress Breast Cancer Metastasis, Targeting Epigenetic Regulator JARID1B in Malignant Melanoma, G7132172585, Development of MassSQUIRM to Quantitatively Measure Lysine Methylation, G7448080449, G748865769, G7670519441, Regulation of alternative cleavage and polyadenylation, G818926117, G8227984658, G8284131928, Broad Shortening of 3' UTRs in Human Cancers: Methods, Target Genes and Functional Consequences, G8449124899, G8742035, G8937439577

OpenAlex ID: W2552021993

FWCI: 1.355

Cites: 80

Cited by: 34

Related to: 10