Get started
Work

AR-12 Inhibits Chaperone Proteins Preventing Virus Replication and the Accumulation of Toxic Misfolded Proteins

Year: 2016
Type: conference-abstract
Abstract: Although originally thought to be an inhibitor of PDK-1, OSU-03012 (AR-12) was shown in 2005 not to primarily act as a PDK-1 inhibitor in its ability to radio-sensitize tumor cells [1,2].Subsequently it was shown that the primary mechanism by which AR-12 killed tumor cells was via the PKR-like endoplasmic reticulum kinase (PERK) -dependent induction of endoplasmic reticulum stress signaling [1][2][3].ER stress signaling in turn promoted a toxic form of autophagy resulting in a necroptotic form of cell death.
DOI: 10.4172/2155-9899.1000454
Authors: Laurence Booth, Jane L Roberts, Heath Ecroyd, St Patrick Reid, Stefan Proniuk, Alexander Zukiwski, Abraham Jacob, Elsa Damonte, Maria J Tunon, Paul Dent
Institutions: Virginia Commonwealth University, University of Wollongong, Illawarra Health and Medical Research Institute, United States Army Medical Research Institute of Infectious Diseases, Arno Therapeutics (United States), University of Arizona, Universidad de Buenos Aires, Universidad de León
Language: English
Open Access status: green
Awards: G2524726931, Pemetrexed and sildenafil for lung cancer, G4347739215, G6027020843, G7808473120, G9000186613, Massey Cancer Center - Cancer Center Support Grant
OpenAlex ID: W2552168394
Cites: 34
Cited by: 8
Related to: 10