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Histological and Morphometrical Studies in Liver Regeneration in Mice

Year: 2012

Type: article

Abstract: Liver regeneration after loss of important cell population is a complex process involving all mature liver cell types.We study the response of hepatocytes in 24h and 48h after partial hepatectomy by microscopic and morphometricanalysis. Thirty adult male NMRI, 8 week old mice were used in the study. Liver regeneration after partialhepatectomy (68%) in mice is a complex process that is performed on account differentiated mature hepatocyteproliferation, as evidenced by the presence of nuclei hypertrophy, binucleate cells or polyploidy, and numerousmitotic figures. Morphometrical analysis of cell size showed increases in average dimension of the control comparedto the experimental groups. After this study, we can conclude that liver regeneration after partial hepatectomy ismarked by the proliferation of liver cell population, while reducing the apoptotic process.

Source: DOAJ (DOAJ: Directory of Open Access Journals)

Authors: Roxana Popescu, Marioara Nicoleta Filimon, Gabi Dumitrescu, Liliana Petculescu Ciochina, Victor Dumitrascu, Daliborca Vlad, Doina Verdes

Institutions: Victor Babeș University of Medicine and Pharmacy Timișoara, West University of Timişoara, Univesity of Life Science "King Mihai I" from Timisoara

Language: English

Topic: Liver physiology and pathology

Subfield: Hepatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2552280502

FWCI:

Cites: 9

Cited by: 9

Related to: 10