Year: 2015
Type: article
Abstract: Trans fatty acids (TFAs) are a recent focus of health problems.TFA is a definitive risk factor for cardiovascular diseases and the death.TF A is also possible risk factor for Alzheimer's disease, obesity, diabetes, fatty liver, and ovulation infertility.The relationship between TF A and carcinogenic risk is controversial; however, TF A is reported to increase the risk of breast cancer and prostate cancer.Elaidic acid (EA), a trans form of oleic acid, enhances cancer cell growth, invasion, and anti-apoptotic survival.In animal models, EA promotes tumor growth and metastasis to the lung, liver, and peritoneum.EA induces sternness in cancer cells through transactivation of EFGR via SRC from GPR40/120 as receptors in EA-integrated cholesterol rafts.Activated EGFR relays the signals to activate canonical and non-canonical wnt pathways and to inactivate notchl pathways.EA also increases miR-494, which inhibits cell differentiation through decrease of target genes.Continuous EA feeding with dosage alteration increased cancer cell sternness.EA diminishes the efficiency of 5-fluorouracil by increasing residual cancer stem cells.These findings suggest that TF A is a relevant cancer promoting factor.The decision to remove TF A from foods made by the FDA might have an impact on cancer clinics.
Authors: Hitoshi Ohmori, Kiyomu Fujii, Hiroki Kuniyasu
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2553161941