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Predictors of short term outcomes in renal allograft recipient's: A prospective study

Year: 2016

Type: article

Abstract: Thrombotic microangiopathy (TMA) is a clinical condition resulting from severe endothelial damage and leading to microangiopathic hemolytic anemia, consumptive thrombocytopenia, and ischemia of distal organs. TMA does not only develop in the native kidney but also appears as a recurrent or de novo condition in the transplanted kidney.Etiology of de novo TMA includes renal ischemia, antibody-mediated rejection, malignancies, viral infections (CMV, parvovirus B19, BK polyomavirus, and HHV-6), antiphospholipid antibodies, anticardiolipin antibodies developing in HCV-positive patients, and medications (calcineurin inhibitors, m-TOR inhibitors, and antiviral medications).Early diagnosis and treatment of TMA can be lifesaving. In this report, we present our experiences of successful treatment of a renal transplant case of TMA due to BK virus, not a frequent cause of TMA. The clinical picture of TMA caused by endothelial damage through cytopathic effects of viral antigens was evaluated in the light of the relevant literature.

Source: Indian Journal of Transplantation

DOI: 10.1016/j.ijt.2016.09.089

Authors: Elenjickal Elias John, J.S. Sandhu, P.M. Sohal, B.S. Aulakh

Institution: Dayanand Medical College & Hospital

Language: English

Topic: Renal Transplantation Outcomes and Treatments

Subfield: Transplantation

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W2553689894

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