Work

Microfluidics‐based 3D cell culture models: Utility in novel drug discovery and delivery research

Year: 2016

Type: review

Abstract: The implementation of microfluidic devices within life sciences has furthered the possibilities of both academic and industrial applications such as rapid genome sequencing, predictive drug studies, and single cell manipulation. In contrast to the preferred two-dimensional cell-based screening, three-dimensional (3D) systems have more in vivo relevance as well as ability to perform as a predictive tool for the success or failure of a drug screening campaign. 3D cell culture has shown an adaptive response to the recent advancements in microfluidic technologies which has allowed better control over spheroid sizes and subsequent drug screening studies. In this review, we highlight the most significant developments in the field of microfluidic 3D culture over the past half-decade with a special focus on their benefits and challenges down the lane. With the newer technologies emerging, implementation of microfluidic 3D culture systems into the drug discovery pipeline is right around the bend.

Source: Bioengineering & Translational Medicine

DOI: 10.1002/btm2.10013

Authors: Nilesh Gupta, Jeffrey R. Liu, Brijeshkumar Patel, Deepak E. Solomon, Bhuvaneshwar Vaidya, Vivek Gupta

Institution: Keck Graduate Institute

Language: English

Topic: 3D Printing in Biomedical Research

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,890