Renal and Cardiovascular Morbidities Associated with APOL1 Status among African-American and Non-African-American Children with Focal Segmental Glomerulosclerosis
Year: 2016
Type: article
Abstract: Background and objectives: African American (AA) children with focal segmental glomerulosclerosis (FSGS) have later onset disease that progresses more rapidly than in non-AA children. It is unclear how APOL1 genotypes contribute to kidney disease risk, progression and cardiovascular morbidity in children. Design, setting, participants, & measurements: We examined the prevalence of APOL1 genotypes and associated cardiovascular phenotypes among children with FSGS in the Chronic Kidney Disease in Children (CKiD) study; an ongoing multicenter prospective cohort study of children aged 1-16 years with mild to moderate kidney disease. Results: A total of 140 AA children in the CKiD study were genotyped. HR APOL1 genotypes were present in 24% of AA children (33/140) and were associated with FSGS, p 3 mg/L (33% vs. 15%, p=0.12) and obesity (48% vs. 19%, p=0.01). There were no differences in glomerular filtration rate, hemoglobin, iPTH, or calcium-phosphate product. Conclusions: AA children with HR APOL1 genotype and FSGS have increase prevalence of obesity and LVH despite a later age of FSGS onset, while adjusting for socioeconomic status. Treatment of obesity may be an important component of CKD and LVH management in this population.
Source: Frontiers in Pediatrics
Institutions: Stony Brook Children's Hospital, Johns Hopkins University, National Cancer Institute, Leidos Biomedical Research Inc. (United States), Children's Hospital at Montefiore, Cincinnati Children's Hospital Medical Center, University of Michigan, Michigan Medicine, University of New Mexico, Children's Mercy Hospital, University of Pennsylvania, National Institutes of Health
Language: English
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
Funders: Children's Hospital of Philadelphia, University of Missouri-Kansas City, Children's Mercy Hospital, National Institutes of Health, Johns Hopkins Bloomberg School of Public Health, Medical Center, University of Rochester, National Heart, Lung, and Blood Institute, National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases, NIH Clinical Center, National Center for Advancing Translational Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: Center for Clinical and Translational Science and Training, Clinical and Translational Science Award, The Kidney Disease in Children Data Management and Analysis Center (KIDMAC), Central Biochemistry Laboratory of the CKiD Consortium, Chronic Kidney Disease in Children (CKiD), APOL1 - associated nephropathy from human-derived, intrarenal perspective, Chronic Kidney Disease in Children (CKiD V)
OpenAlex ID: W2554076427