Epigenetic therapy in a new era of medicine: creating and integrating molecular profiles of patients
Year: 2016
Type: article
Abstract: In the 17 th century, Antonie von Leeuwenhoek revolutionized microbiology with the advent of the microscope. Today we are in a similar revolution for cancer and genetics with the development of sequencing technology as "molecular microscopes" to peer into cells and catalog their genetic and epigenetic changes. We now have the capabilities to study diseases like cancer and how tumors evolve via single-cell sequencing and dynamics (1,2). Sequencing has gone far to transform the way we understand and view the central dogma of biology (3). While the central dogma of molecular biology is still a guiding framework for understanding disease (DNA to RNA to protein), we are beginning to understand the panoply of regulatory levers and mechanisms that guide—and even deviate—from such an orderly progression of molecular relationships, especially in the context of diseases like cancer.
Source: Annals of Translational Medicine
Authors: Ebrahim Afshinnekoo, Christopher E. Mason
Institutions: New York Medical College, Weill Cornell Medicine
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Funders: National Aeronautics and Space Administration, Bill and Melinda Gates Foundation, Alfred P. Sloan Foundation, Vallee Foundation, Pershing Square Sohn Cancer Research Alliance, WorldQuant Foundation, National Institutes of Health, Weill Cornell Medical College, National Institute of Allergy and Infectious Diseases, National Institute of Neurological Disorders and Stroke, National Institute of Environmental Health Sciences, National Institute of Biomedical Imaging and Bioengineering
Awards: G1284901464, G232304109, NEXT-GENERATION SEQUENCING (NGS) TECHNOLOGIES HAVE RECENTLY BEEN USED TO DETECT AND CLASSIFY EPIGENETIC CHANGES AT AN UNPRECEDENTED LEVEL. EPIGENETIC, G4198848887, Community Research Education and Engagement for Data Science (CREEDS), Study of Neural Tube Defects Etiology: Genome and Exposome, Joan & Sanford I. Weill Medical College of Cornell University - to monitor the spread of antimicrobial resistance by generating a global map of bacterial species, resistance genes and markers, and modified bases..., Research - Weill Cornell Medical College (2015), Epigenome Interactions in Complex Neurogenetic Disorders, G7649130910, G9000163900
OpenAlex ID: W2554219782