Work

Telavancin Is Active against Experimental Aortic Valve Endocarditis Caused by Daptomycin- and Methicillin-Resistant Staphylococcus aureus Strains

Year: 2016

Type: article

Abstract: ABSTRACT We compared the efficacy of telavancin (TLV) and daptomycin (DAP) in an experimental rabbit endocarditis model caused by two clinically derived daptomycin-resistant (DAP r ) methicillin-resistant Staphylococcus aureus (MRSA) strains. TLV treatment significantly reduced MRSA densities in all target tissues and increased the percentage of these organs rendered culture negative compared to those with the untreated control or DAP-treated animals. These results demonstrate that TLV has potent in vivo efficacy against DAP r MRSA isolates in this invasive endovascular infection model.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.01877-16

Authors: Wessam Abdelhady, Arnold S. Bayer, Rachelle Gonzales, Liang Li, Yan Q. Xiong

Institutions: University of California, Los Angeles, The Lundquist Institute, Harbor–UCLA Medical Center

Language: English

Topic: Antimicrobial Resistance in Staphylococcus

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of Allergy and Infectious Diseases