Year: 2016
Type: conference-abstract
Abstract: Case Report:A 52 years old man seen in the renal clinic for persistent proteinuria and leg swelling.He also had weight loss, diarrhea for 6 months and getting SOB.Initial impression was Nephrotic syndrome.Background: Hypertension and chronic depression.Drug Hx: Olanzapine, Venlafaxine, Ramipril.Examination: Erythematous rash over the face, limbs and abdomen exacerbated by stress intermittently.Palpable liver of 3-4 cm with lower limbs and peri-orbital swelling.Investigations: Abdominal US showed grossly enlarged and irregular liver containing multiple lesions of varying echotextures.It was confirmed by CT which also showed a well defined lesion in the mesentery.Liver biopsy confirmed neuroendocrine tumor showing strong positive staining for CD56, chromogranin, NSE and synaptophysin.Ki67 was 3%.Echo showed signs of right sided heart involvement with severe tricuspid regurgitation and pulmonary stenosis.Interestingly repeat Echocardiogram after a week showed a new onset aortic regurgitation and so confirmed left sided involvement.24 hours Urinary 5-HIAA was significantly raised at 1384 micromole.He was referred to neuroendocrine MDT.
Source: Endocrine Abstracts
Authors: Khwaja Nizamuddin, Sajjad Ahmad, Rajesh Thaman, David Glover
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2555813305