Work

Circulating biomarkers of oxidative stress in chronic obstructive pulmonary disease: a systematic review

Year: 2016

Type: review

Abstract: Chronic obstructive pulmonary disease (COPD) is a progressive condition characterized by airflow limitation associated with an abnormal inflammatory response of the lungs to noxious particles and gases, caused primarily by cigarette smoking. Increased oxidative burden plays an important role in the pathogenesis of COPD. There is a delicate balance between the toxicity of oxidants and the protective function of the intracellular and extracellular antioxidant defense systems, which is critically important for the maintenance of normal pulmonary functions. Several biomarkers of oxidative stress are available and have been evaluated in COPD. In this review, we summarize the main literature findings about circulating oxidative stress biomarkers, grouped according to their method of detection, measured in COPD subjects.

Source: Respiratory Research

DOI: 10.1186/s12931-016-0471-z

Authors: Elisabetta Zinellu, Angelo Zinellu, Alessandro Giuseppe Fois, Ciriaco Carru, Pietro Pirina

Institutions: Azienda Ospedaliero Universitaria di Sassari, University of Sassari

Language: English

Topic: Chronic Obstructive Pulmonary Disease (COPD) Research

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,490