Work

Histone Demethylases and Their Roles in Cancer Epigenetics

Year: 2016

Type: article

Abstract: The genetic abnormalities that drive tumorigenesis are usually coupled with epigenetic alterations, such as DNA methylation and aberrant histone modifications, which may help oncogenic drivers accelerate cancer progression, metastasis, and therapy resistance. The discovery of histone demethylases has provided us new insight for understanding the epigenetic landscape of the chromatin environment of cancer cells. This review aims to summarize the current knowledge on the human histone lysine demethylases and their functions in cancers, and recent advances in development of small molecule inhibitors to target histone demethylases in cancer treatment.

DOI: 10.35841/medical-oncology.1.2.34-40

Authors: Alexandra D'Oto, Qing-wu Tian, Andrew M Davidoff, Jun Yang

Institutions: St. Jude Children's Research Hospital, Affiliated Hospital of Qingdao University

Language: English

Topic: Epigenetics and DNA Methylation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Assisi Foundation of Memphis, American Lebanese Syrian Associated Charities, National Cancer Institute

Awards: G1139922818, Studies of Childhood Solid Tumors, G6478128110, G8386741907