Fatty Acid Binding Protein 3 (FABP3) Deficiency Does Not Impact on Feto-Placental Morphometry and Fatty Acid Transporters in Mice
Year: 2015
Type: article
Abstract: In most mammals, proper placentation along with its morphology is critical for fetal development and pregnancy success. Fatty acid binding protein 3 (FABP3) has been shown to regulate the transportation of polyunsaturated fatty acid (PUFA) to the fetus, but its impact on placental morphology and genetic alteration of fatty acid transporters in trophoblast cells is still unknown. Using mice model we found FABP3 deficiency does not affect the morphology of placenta along with the gene of fatty acid transporters. FABP3 deficiency was also found to have no impact on the morphology of human trophoblast cells (BeWo cells) in in vitro study. Fatty acid transporter genes were also remains unaltered after FABP3 knockdown. Our study suggests that placenta may conserve its morphology and genetics although it has PUFAs deficiency.
Source: Bioresearch Communications
Authors: Ariful Islam, Yuji Owada
Institution: Yamaguchi University
Language: English
Subfield: Obstetrics and Gynecology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W2555981145