Year: 2016
Type: review
Abstract: Actin polymerization governs activity-dependent modulation of excitatory synapses, including their morphology and functionality. It is clear from human genetics that neuropsychiatric and neurodevelopmental disturbances are multigenetic in nature, highlighting the need to better understand the critical neural pathways associated with these disorders and how they are altered by genetic risk alleles. One such signaling pathway that is heavily implicated by candidate genes for psychiatric and neurodevelopmental disorders are regulators of signaling to the actin cytoskeleton, suggesting that its disruption and the ensuring abnormalities of spine structures and postsynaptic complexes is a commonly affected pathway in brain disorders. This review will discuss recent experimental findings that strongly support genetic evidence linking the synaptic cytoskeleton to mental disorders, such as schizophrenia and autism spectrum disorders.
Source: Journal of Neuroscience
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: hybrid
Awards: Functions of D4 Dopamine Receptors in Prefrontal Cortex, Prefrontal microcircuitry and cognition in schizophrenia, Fragile X Phenotypes Modulated by Altered Signaling to the Synaptic Cytoskeleton, Cortical Cells Circuits Connectivity and Cognition in Schizophrenia, Fragile X Phenotypes Modulated by Altered Signaling to the Synaptic Cytoskeleton, Molecular, Synaptic, and Circuit Basis for Schizophrenia-related Phenotypes, G6611632239, Physiological and Pathophysiological Basis of Stress, GABA Neurons and Cortical Circuitry in Schizophrenia, G9000019901, G9000122926, G9000168192
OpenAlex ID: W2556865101