Work

Palladium-Catalyzed Transformations of Alkyl C–H Bonds

Year: 2016

Type: review

Abstract: This Review summarizes the advancements in Pd-catalyzed C(sp 3 )–H activation via various redox manifolds, including Pd(0)/Pd(II), Pd(II)/Pd(IV), and Pd(II)/Pd(0). While few examples have been reported in the activation of alkane C–H bonds, many C(sp 3 )–H activation/C–C and C–heteroatom bond forming reactions have been developed by the use of directing group strategies to control regioselectivity and build structural patterns for synthetic chemistry. A number of mono- and bidentate ligands have also proven to be effective for accelerating C(sp 3 )–H activation directed by weakly coordinating auxiliaries, which provides great opportunities to control reactivity and selectivity (including enantioselectivity) in Pd-catalyzed C–H functionalization reactions.

Source: Chemical Reviews

DOI: 10.1021/acs.chemrev.6b00622

Authors: Jian He, Masayuki Wasa, Kelvin S. L. Chan, Qian Shao, Jin-Quan Yu

Institution: Scripps Research Institute

Language: English

Topic: Catalytic C–H Functionalization Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green