A phase I/II trial of AT9283, a selective inhibitor of aurora kinase in children with relapsed or refractory acute leukemia: challenges to run early phase clinical trials for children with leukemia
Year: 2016
Type: article
Study design: Clinical Trial
Abstract: Aurora kinases regulate mitosis and are commonly overexpressed in leukemia. This phase I/IIa study of AT9283, a multikinase inhibitor, was designed to identify maximal tolerated doses, safety, pharmacokinetics, and pharmacodynamic activity in children with relapsed/refractory acute leukemia. The trial suffered from poor recruitment and terminated early, therefore failing to identify its primary endpoints. AT9283 caused tolerable toxicity, but failed to show clinical responses. Future trials should be based on robust preclinical data that provide an indication of which patients may benefit from the experimental agent, and recruitment should be improved through international collaborations and early combination with established treatment strategies.
Source: Pediatric Blood & Cancer
DOI: 10.1002/pbc.26351
Authors: B. Vormoor, G. J. Veal, M. J. Griffin, A. V. Boddy, J. Irving, L. Minto, M. Case, U. Banerji, K. E. Swales, J. R. Tall, A. S. Moore, M. Toguchi, G. Acton, K. Dyer, C. Schwab, C. J. Harrison, J. D. Grainger, D. Lancaster, P. Kearns, D. Hargrave, J. Vormoor
Institutions: Newcastle upon Tyne Hospitals NHS Foundation Trust, Great North Children's Hospital, Newcastle University, The University of Sydney, Institute of Cancer Research, Cancer Research UK, Royal Marsden Hospital, The University of Queensland, Manchester Academic Health Science Centre, University of Manchester, Royal Manchester Children's Hospital, University of Birmingham, Great Ormond Street Hospital
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: G3601372966, G3823999362
OpenAlex ID: W2557725129