Challenges and opportunities for system biology standards and tools in medical research
Year: 2016
Type: conference-paper
Abstract: Kinetic models are increasingly relevant in medical research. In systems biology, more than 10 years of experience with the development of standards and tools to construct and analyse kinetic models exists. This has supported the sharing of kinetic models, increased their reuse, and thereby has helped to reproduce and validate scientific results. Given this expertise, it seems natural to consider the application and development of standards and tools to meet the requirements of medical scientists. In this paper, we discuss challenges and opportunities for standards and tools from systems biology in medical research, and we suggest criteria for the safe use of simulations. We conclude that standards, tools and infrastructure need to be extended to ensure the quality, reliability and safety required when working with medical and patient data. This will foster the adaptation of modelling in the clinic, providing tools for improved diagnosis, prognosis and therapy.
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Funders: National Institute for Social Care and Health Research, Wellcome Trust, Heising-Simons Foundation, Cancer Research UK, National Institute for Health and Care Research, British Heart Foundation, Bundesministerium für Bildung und Forschung, Medical Research Council, Engineering and Physical Sciences Research Council, Economic and Social Research Council, Menzies Centre for Australian Studies, King's College London, University of London
OpenAlex ID: W2557759663