Association of SIRT6 Gene Polymorphisms with Human Longevity.
Year: 2016
Type: article
Study design: Observational Study
Abstract: BACKGROUND: 6 gene polymorphism rs350846 in human longevity. METHODS: 6 C/G genotypes were determined using Taqman SNP Genotyping Assays in 169 long-lived inhabitants (LG group aged 90-110 yr), 158 healthy internal controls (internal control group; aged 26-82 yr) and 176 healthy external controls (external control group; aged 20-82 yr) without a family history of exceptional longevity. Statistical analysis was conducted using SPSS 16.0. RESULTS: 6 was much higher in the external control than in the other groups. BMI, SBP and HDL-c displayed significant effect on longevity. CONCLUSION: 6 gene, CC and CG genotypes as well as BMI, systolic pressure and HDL-c are associated with longevity. Further studies are needed to validate our results.
Source: PubMed Central
Authors: You Li, Jian Qin, Xiao Wei, Guiyun Liang, Liwei Shi, Meiyu Jiang, Tianlong Xia, Xue Liang, Min He, Zhiyong Zhang
Institution: Guangxi Medical University
Language: English
Subfield: Geriatrics and Gerontology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2557983130