Work

Tank-Binding Kinase 1 (TBK1) Gene and Open-Angle Glaucomas (An American Ophthalmological Society Thesis).

Year: 2016

Type: article

Abstract: PURPOSE: ) gene copy-number variations (ie, gene duplications and triplications) in the pathophysiology of various open-angle glaucomas. METHODS: gene are associated with normal-tension glaucoma. Here, we investigated the prevalence of copy-number variations in cohorts of patients with other open-angle glaucomas-juvenile-onset open-angle glaucoma (n=30), pigmentary glaucoma (n=209), exfoliation glaucoma (n=225), and steroid-induced glaucoma (n=79)-using a quantitative polymerase chain reaction assay. RESULTS: gene duplication was detected in one (0.44%) of the 225 exfoliation glaucoma patients. CONCLUSIONS: copy-number variations, although mutations in this gene are most often detected in patients with normal-tension glaucoma.

Source: PubMed